Leonard J. Giblin, III, M.D., Ph.D.

 (409) 765-7620

leonardgiblin@yahoo.com

GRADUATE EDUCATION

 

The University of Texas Medical Branch – Galveston

    Doctor of Medicine                                                                                                     June 2003

            Received Honors in Radiology  

    Doctor of Philosophy                                                                                                  April 2001

            Cellular Physiology and Molecular Biophysics Program

      Dissertation: “Differential Interactions Between the Ryanodine-Sensitive Calcium Store and Calcium Influx Pathways in a Retinal Neuron”

Received the Rose and Harry Walk Research Award

 

EXPERIENCE

 

Scientific, Medical & Engineering Consultant                                             2008 – present

                                                                                                                                  

Chief Medical Advisor & Board Member                                                          2009 – 2010

Regenetech, Inc., Houston, TX                                                                   

 

Chief Scientist & Biomedical Engineer                                              January 2004 – 2008

NeuroBioTex, Inc., Galveston, TX                                                

   Performed mechanical, electrical and software (Visual Basic) engineering

   Developed fluorometric assay for the quantification of zinc in prostatic secretions

   Obtained IRB approval from participating institutions and acted as liaison and recruiter for participating physicians

   A report on a recent prostate screening event with an audio interview of Dr. Giblin is available at http://www.guidrynews.com/story.aspx?id=1000007033

 

 

 

Chief Engineer                                                                                                 2003 – present

Diluvian Technologies, LLC, Galveston, TX                                               

   Performed all mechanical, electrical, software (QBasic, registry level) engineering and design (video of the system in operation is available)

   Integrates automated solution changes with automated drying, and eliminates the production of volatile fixative fumes with continuous sample coverage

 

Cytogenetic Technician (2 years)

Laboratories for Genetic Services, Houston, TX

Fabricated sample covers to minimize the production of volatile fixative fumes and fine-tuned the software for precise positioning of dispensing and aspirating

Performed the system validation tests

   This experimental apparatus eliminated the variability of harvest quality between technicians and improved overall harvest quality and consistency.  It also cut the technician time devoted to harvesting by over one half.

 

Mechanic – Classic British Automobiles (part-time during college)

London Bridge, Ltd., Austin, TX

 

TEACHING

Adjunct Professor, University of Houston – Clear Lake

School of Science and Computer Engineering

            Undergraduate Courses

                        Human Physiology

                        Human Anatomy

            Graduate Courses

                        Pathophysiology

                        Pharmacology

 

Guest Lecturer in Systemic Physiology and Tools for Translational Biology

Graduate School of Biomedical Sciences, University of Texas Medical Branch – Galveston

            2008 Lectures: “The Heart as a Pump” and “Overview of Renal Physiology”

 

RECENT SYMPOSIA / PRESENTATIONS

 

2009 Cancer Stem Cell Symposium:  Stem Cells and Novel Hallmarks of Carcinogenesis for the Management of Cancer. November 9-10, 2009, Seoul National University, S. Korea. Presentation of NASA data:  “3-Dimensional Tissue Growth (“Engineered” Tissue for Regenerative Purposes)”

 

ADDITIONAL EXPERIENCE AND SKILLS

Cellular Electrophysiology: patch and whole-cell voltage clamping, micromanipulation

 

Confocal Microscopy: Installation and operation

 

Spectrophotometry, Fluorescence Microscopy, Immunohistochemistry, Tissue Culture, Western Blots

 

GLP, GMP, Machining and Prototyping, CAD (SolidEdge, Seimens)

 

Computing: MSWord, Excel, PowerPoint, Networking, Programming in QBasic and Visual Basic

 

 

RECENT PUBLICATIONS

 

Bozym RA, Chimienti F, Giblin LJ, Gross GW, Korichneva I, Li Y, Libert S, Maret W, Parviz M, Frederickson CJ, Thompson RB.  Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro.  Exp Biol Med (Maywood). 2010 Jun;235(6):741-50.

 

Linkous DH, Flinn JM, Koh JY, Lanzirotti A, Bertsch PM, Jones BF, Giblin LJ, Frederickson CJ.  Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles. J Histochem Cytochem. 2008 Jan;56(1):3-6.

 

Frederickson C, Frederickson CJ, Maret W, Sandstead H, Giblin L, Thompson R.

Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biology.

Science STKE. 2007 Nov 6;2007(411):pe61.

 

Giblin LJ, Chang CJ, Bentley AF, Frederickson C, Lippard SJ, Frederickson CJ.  Zinc-secreting Paneth cells studied by ZP fluorescence. J Histochem Cytochem. 2006 Mar. 54(3): 311-6.

 

Frederickson CJ, Giblin LJ, Rengarajan B, Masalha R, Frederickson C, Zeng Y, Lopez EV, Koh JY, Chorin U, Besser L, Hershfinkel M, Li Y, Thompson RB, Krezel A. Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods. 2006 Jun 30;154(1-2):19-29

 

Frederickson CJ, Giblin LJ, Krezel A, McAdoo DJ, Muelle RN, Zeng Y, Balaji RV, Masalha R, Thompson RB, Fierke CA, Sarvey JM, de Valdenebro M, Prough DS, Zornow MH.  Concentrations of extracellular free zinc (pZn)(e) in the central nervous system during simple anesthetization, ischemia and reperfusion.  Exp Neurol. 2006 Apr;198(2):285-93

 

Frederickson, C.J., Hershfinkel, M. and Giblin, L.J.  The Gluzinergic Synapse: Who’s Talking and Who’s Listening?  In Synaptic Plasticity and Transsynaptic Signaling, eds. Stanton, P.K., Bramham, C. and Scharfman, H.E., Ch. 9, pp. 123-137.  Springer, New York, 2005.

 

PATENTS:    #20050238543  Metered dispenser and aspirator device. Awarded October, 2008.