Leonard J. Giblin, III, M.D., Ph.D.
Doctor of Medicine June 2003
Received Honors in Radiology
Doctor of Philosophy April 2001
Cellular Physiology and Molecular Biophysics Program
Dissertation: “Differential Interactions Between the Ryanodine-Sensitive Calcium Store and Calcium Influx Pathways in a Retinal Neuron”
Received the Rose and Harry Walk Research Award
NeuroBioTex, Inc., Galveston, TX
Performed mechanical, electrical and software (Visual Basic) engineering
Developed fluorometric assay for the quantification of zinc in prostatic secretions
Obtained IRB approval from participating institutions and acted as liaison and recruiter for participating physicians
A report on a recent prostate screening event with an audio interview of Dr. Giblin is available at http://www.guidrynews.com/story.aspx?id=1000007033
Diluvian Technologies, LLC, Galveston, TX
Performed all mechanical, electrical, software (QBasic, registry level) engineering and design (video of the system in operation is available)
Integrates automated solution changes with automated drying, and eliminates the production of volatile fixative fumes with continuous sample coverage
Cytogenetic Technician (2 years)
Laboratories for Genetic Services, Houston, TX
Fabricated sample covers to minimize the production of volatile fixative fumes and fine-tuned the software for precise positioning of dispensing and aspirating
Performed the system validation tests
This experimental apparatus eliminated the variability of harvest quality between technicians and improved overall harvest quality and consistency. It also cut the technician time devoted to harvesting by over one half.
London Bridge, Ltd., Austin, TX
School of Science and Computer Engineering
Graduate School of Biomedical Sciences, University of Texas Medical Branch – Galveston
2008 Lectures: “The Heart as a Pump” and “Overview of Renal Physiology”
2009 Cancer Stem Cell Symposium: Stem Cells and Novel Hallmarks of Carcinogenesis for the Management of Cancer. November 9-10, 2009, Seoul National University, S. Korea. Presentation of NASA data: “3-Dimensional Tissue Growth (“Engineered” Tissue for Regenerative Purposes)”
Bozym RA, Chimienti F, Giblin LJ, Gross GW, Korichneva I, Li Y, Libert S, Maret W, Parviz M, Frederickson CJ, Thompson RB. Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro. Exp Biol Med (Maywood). 2010 Jun;235(6):741-50.
Linkous DH, Flinn JM, Koh JY, Lanzirotti A, Bertsch PM, Jones BF, Giblin LJ, Frederickson CJ. Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles. J Histochem Cytochem. 2008 Jan;56(1):3-6.
Frederickson C, Frederickson CJ, Maret W, Sandstead H, Giblin L, Thompson R.
Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biology.
Science STKE. 2007 Nov 6;2007(411):pe61.
Giblin LJ, Chang CJ, Bentley AF, Frederickson C, Lippard SJ, Frederickson CJ. Zinc-secreting Paneth cells studied by ZP fluorescence. J Histochem Cytochem. 2006 Mar. 54(3): 311-6.
Frederickson CJ, Giblin LJ, Rengarajan B, Masalha R, Frederickson C, Zeng Y, Lopez EV, Koh JY, Chorin U, Besser L, Hershfinkel M, Li Y, Thompson RB, Krezel A. Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods. 2006 Jun 30;154(1-2):19-29
Frederickson CJ, Giblin LJ, Krezel A, McAdoo DJ, Muelle RN, Zeng Y, Balaji RV, Masalha R, Thompson RB, Fierke CA, Sarvey JM, de Valdenebro M, Prough DS, Zornow MH. Concentrations of extracellular free zinc (pZn)(e) in the central nervous system during simple anesthetization, ischemia and reperfusion. Exp Neurol. 2006 Apr;198(2):285-93
Frederickson, C.J., Hershfinkel, M. and Giblin, L.J. The Gluzinergic Synapse: Who’s Talking and Who’s Listening? In Synaptic Plasticity and Transsynaptic Signaling, eds. Stanton, P.K., Bramham, C. and Scharfman, H.E., Ch. 9, pp. 123-137. Springer, New York, 2005.
PATENTS: #20050238543 Metered dispenser and aspirator device. Awarded October, 2008.